Although it never achieved the mainstream success of "Chop Suey!" and "B.Y.O.B", Toxicity remains one of System of a Down's most popular songs among fans. The song was ranked #14 on VH1's 40 Greatest Metal Songs .
The song is in C minor key and it is played on dropped C tuned guitar.
The video was directed by Shavo Odadjian.
The beginning of the video shows the streets of Los Angeles, California, then cuts to the band. Daron Malakian can be seen wearing a Los Angeles Kings jersey with his last name on the back most of the time in the video. During the verses, a projector shows homeless people lined against the streets. The end of the video is a reference to a Pantera music video.